Mitochondria-targeting tetrapeptide.
SS-31 (elamipretide, bendavia) is a synthetic tetrapeptide developed in the Szeto–Schiller laboratory at Weill Cornell. The compound is described as a prototype "mitochondria-targeted" antioxidant that preferentially accumulates on the inner mitochondrial membrane. Supplied as research-grade material with 3rd-party HPLC verification and full Certificate of Analysis per lot.
SS-31 (elamipretide, bendavia) is a synthetic tetrapeptide developed in the Szeto–Schiller laboratory at Weill Cornell. The compound is described as a prototype "mitochondria-targeted" antioxidant that preferentially accumulates on the inner mitochondrial membrane.
SS-31 binds cardiolipin — a phospholipid found almost exclusively on the inner mitochondrial membrane — and is described in the literature as stabilizing cardiolipin-associated proteins in the electron transport chain. Published work attributes reported effects to preservation of mitochondrial cristae architecture and reduction of reactive oxygen species leakage at respiratory complexes I and III.
SS-31 (as elamipretide) has been investigated in multiple clinical trials for mitochondrial diseases including Barth syndrome, primary mitochondrial myopathy, and heart failure with preserved ejection fraction. It is not yet an FDA-approved drug; development is ongoing under the name Bendavia/Elamipretide.
The above summarizes published research literature. This is not medical advice, a protocol, or a recommendation for use. This compound is supplied for laboratory research only.
SS-31 is a 4-residue peptide with molecular formula C32H49N9O5 and molecular weight of approximately 639.8 Da.
The full structural data and release specifications are in the Compound Profile section above. Every lot ships with an independently verified Certificate of Analysis.
Each lot is independently verified by a 3rd-party analytical laboratory (STERIS Labs, Alcami Analytical, or equivalent) before release. Release specification is HPLC purity ≥ 99.5% (typical > 99.8%), mass spectrometry identity match within ±0.5 Da, water content < 5.0% Karl Fischer, and endotoxin < 0.25 EU/mL by LAL (USP <85>).
Look up the full COA for your lot at coa-lookup.html.
All compounds ship at ambient temperature in discreet, tamper-evident packaging. Lyophilized peptide powder is stable at room temperature for typical transit windows, which is why research-grade vendors ship this way. Tracked; signature not required.
Store unopened lyophilized product at 2–8°C protected from light. Once reconstituted, most peptides are stable at 2–8°C for approximately 28 days (compound-dependent).
SS-31 (as elamipretide) has been investigated in multiple clinical trials for mitochondrial diseases including Barth syndrome, primary mitochondrial myopathy, and heart failure with preserved ejection fraction. It is not yet an FDA-approved drug; development is ongoing under the name Bendavia/Elamipretide.
All PeptideBros compounds are sold strictly as chemical reference materials for in-vitro laboratory research. They are not for human consumption.
HPLC-verified. Mass-spec confirmed. Ambient-stable transit. The paperwork other vendors hope you never ask for.