Mitochondrial-derived peptide.
MOTS-c ("mitochondrial open reading frame of the twelve S rRNA-c") is a 16-residue peptide encoded within the mitochondrial 12S rRNA region — one of the first biologically active peptides identified as being encoded in mitochondrial DNA. Supplied as research-grade material with 3rd-party HPLC verification and full Certificate of Analysis per lot.
MOTS-c ("mitochondrial open reading frame of the twelve S rRNA-c") is a 16-residue peptide encoded within the mitochondrial 12S rRNA region — one of the first biologically active peptides identified as being encoded in mitochondrial DNA.
First characterized by Lee and Cohen at USC (2015), MOTS-c is described in the literature as a regulator of metabolic homeostasis. Reported pathways include activation of AMPK signaling, enhancement of GLUT4-mediated glucose uptake in skeletal muscle, and modulation of mitochondrial folate-methionine cycle flux. Published work describes it as translocating to the nucleus under metabolic stress to regulate stress-response gene expression.
MOTS-c is not an FDA-approved drug. It is widely available as a research compound and is not a scheduled substance. The compound has attracted interest in longevity and metabolic research communities.
The above summarizes published research literature. This is not medical advice, a protocol, or a recommendation for use. This compound is supplied for laboratory research only.
MOTS-c is a 16-residue peptide with molecular formula C99H158N26O25S2 and molecular weight of approximately 2,174 Da.
The full structural data and release specifications are in the Compound Profile section above. Every lot ships with an independently verified Certificate of Analysis.
Each lot is independently verified by a 3rd-party analytical laboratory (STERIS Labs, Alcami Analytical, or equivalent) before release. Release specification is HPLC purity ≥ 99.5% (typical > 99.8%), mass spectrometry identity match within ±0.5 Da, water content < 5.0% Karl Fischer, and endotoxin < 0.25 EU/mL by LAL (USP <85>).
Look up the full COA for your lot at coa-lookup.html.
All compounds ship at ambient temperature in discreet, tamper-evident packaging. Lyophilized peptide powder is stable at room temperature for typical transit windows, which is why research-grade vendors ship this way. Tracked; signature not required.
Store unopened lyophilized product at 2–8°C protected from light. Once reconstituted, most peptides are stable at 2–8°C for approximately 28 days (compound-dependent).
MOTS-c is not an FDA-approved drug. It is widely available as a research compound and is not a scheduled substance. The compound has attracted interest in longevity and metabolic research communities.
All PeptideBros compounds are sold strictly as chemical reference materials for in-vitro laboratory research. They are not for human consumption.
HPLC-verified. Mass-spec confirmed. Ambient-stable transit. The paperwork other vendors hope you never ask for.