NAD+ is a dinucleotide coenzyme central to cellular redox metabolism — the essential cofactor for sirtuins, PARPs, and the mitochondrial electron transport chain. Supplied as a lyophilized powder in sterile vials with 3rd-party HPLC verification and full Certificate of Analysis per lot.
NAD+ is a dinucleotide coenzyme present in every living cell. Originally characterized in the early 1900s work on alcoholic fermentation by Harden and Young, it is one of the most studied small molecules in all of biochemistry. Its role as a redox cofactor in cellular metabolism is foundational textbook material — every undergraduate biochemistry course covers the NAD+/NADH cycle.
The more recent research interest — accelerated by the laboratories of Leonard Guarente, Shin-ichiro Imai, David Sinclair, and others — centers on NAD+'s role as a rate-limiting substrate for three families of consumer enzymes: sirtuins (NAD+-dependent deacetylases implicated in longevity signaling), PARPs (poly-ADP-ribose polymerases involved in DNA damage response), and CD38 (a major cellular NAD+ase whose activity increases with age).
Published studies describe cellular NAD+ levels as declining substantially with age across multiple tissues in mammalian models. This decline is associated in the literature with reduced sirtuin activity, impaired mitochondrial function, and diminished DNA repair capacity. The central research hypothesis investigated in numerous published studies is whether restoring NAD+ can rescue these downstream activities.
Published work has examined both direct NAD+ administration and precursor supplementation (nicotinamide riboside, NR; nicotinamide mononucleotide, NMN) as strategies to elevate cellular NAD+ pools. Direct NAD+ is generally characterized in the literature as having poor oral bioavailability due to hydrolysis in the GI tract — hence the research interest in IV/SC administration routes and precursor approaches.
NAD+ is a naturally occurring coenzyme. It is not a pharmaceutical drug and is not approved by the FDA to prevent, treat, or cure any medical condition. It exists in a regulatory landscape that includes dietary supplement status for oral formulations and research-compound status for lyophilized laboratory-grade preparations.
Supplied as a white to off-white hygroscopic crystalline powder. The compound is highly water-soluble and moderately stable in neutral-pH aqueous solution at 2–8°C; it is sensitive to light, heat, and hydrolysis. Dry lyophilized storage under refrigeration is required for stability. Reconstituted solutions should be used within a limited window per published stability data and protected from light.
The above summarizes published research literature. This is not medical advice, a protocol, or a recommendation for use. This compound is supplied for laboratory research only.
Every lot is tested by an independent 3rd-party analytical laboratory before release. The standard analytical panel includes reverse-phase HPLC (minimum 99.5% release spec, typically >99.9%), mass spectrometry for identity confirmation, Karl Fischer for water content, LAL assay for endotoxin (<0.25 EU/mL), bioburden, and sterility testing per USP <71>.
The resulting Certificate of Analysis PDF is attached to every order and is lookup-able by lot number after the fact.
NAD+ is the active coenzyme itself. NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) are metabolic precursors — smaller molecules cells convert into NAD+ through the salvage pathway. Published research uses all three approaches to investigate elevating cellular NAD+ pools.
The practical distinction in the literature: direct NAD+ is a large, polar molecule with limited oral bioavailability and rapid hydrolysis in the GI tract, so research uses IV/SC routes of administration. Precursors like NR and NMN are smaller, more bioavailable orally, and are metabolized into NAD+ intracellularly. The three molecules are related but not interchangeable for every research purpose.
NAD+ is more storage-sensitive than most peptides because it's hygroscopic and prone to hydrolysis and oxidation. The lyophilized powder is still stable at ambient temperature for typical transit windows, but should be refrigerated (2–8°C) immediately on receipt. Ships in discreet, desiccant-sealed, light-protective packaging with carrier tracking.
Upon receipt, store the unopened lyophilized vial refrigerated at 2–8°C, protected from light and moisture. The lyophilized form is reported stable for 12–24 months under these conditions. Once reconstituted, the solution degrades faster than peptides — use within a few days to a few weeks depending on buffer conditions, and keep refrigerated and protected from light. Do not freeze the reconstituted solution as this can alter crystallization behavior on re-warming.
NAD+ is a dinucleotide coenzyme with a molecular formula of C21H27N7O14P2 and a molecular weight of approximately 664 Da (free-acid form). Its structure consists of two nucleosides — one carrying nicotinamide, the other carrying adenine — linked by a pyrophosphate bridge.
The supplied material is the oxidized form (NAD+), which is the substrate form consumed by sirtuins, PARPs, and CD38. The reduced form (NADH) is generated as NAD+ accepts hydride during metabolic reactions. Appearance: white to off-white hygroscopic lyophilized powder.
All compounds are synthesized by qualified partner laboratories operating under standard peptide synthesis practices. Synthesis records, raw material provenance, and release testing are documented in the lot file.
Each lot is independently verified by a 3rd-party analytical lab — not our in-house testing — before release. The COA PDF identifies the release lab, the method, and the analyst.
Domestic US shipping to all 50 states via USPS / UPS. Tracking provided at dispatch. International shipping is evaluated on a case-by-case basis due to jurisdictional import regulations.
All products offered on this site are intended for laboratory research purposes only. They are not for human consumption, oral ingestion, or any form of in-vivo use in humans or animals. These compounds are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease.
By placing an order you acknowledge that you are a qualified researcher over the age of 21 and that you assume all responsibility for handling, storage, and end use of the compounds in accordance with applicable law.
HPLC-verified. Mass-spec confirmed. Ambient-stable transit. The paperwork other vendors hope you never ask for.
⚠ ALL PRODUCTS ARE INTENDED FOR LABORATORY RESEARCH PURPOSES ONLY. NOT FOR HUMAN CONSUMPTION, ORAL INGESTION, OR ANY FORM OF IN-VIVO USE IN HUMANS OR ANIMALS. THESE COMPOUNDS ARE NOT MEDICINES OR DRUGS AND HAVE NOT BEEN APPROVED BY THE FDA. BY PLACING AN ORDER YOU ACKNOWLEDGE YOU ARE A QUALIFIED RESEARCHER OVER THE AGE OF 21.