GRF(1-29) · endogenous fragment.
Sermorelin is the 1-29 amino-terminal fragment of human GHRH — the shortest sequence retaining full receptor activity. Originally developed and FDA-approved (as Geref) for diagnostic testing of pituitary GH reserve. Supplied as research-grade material with 3rd-party HPLC verification and full Certificate of Analysis per lot.
Sermorelin is the 1-29 amino-terminal fragment of human GHRH — the shortest sequence retaining full receptor activity. Originally developed and FDA-approved (as Geref) for diagnostic testing of pituitary GH reserve.
Sermorelin binds the GHRH receptor on anterior pituitary somatotrophs. Unlike the GHRPs (which act at the ghrelin receptor), sermorelin acts via the endogenous GHRH pathway, producing pulsatile, GH-specific stimulation without off-target effects on cortisol, prolactin, or ACTH.
Sermorelin was FDA-approved as Geref (Serono) for diagnostic use in GH-deficient children, though the brand was discontinued. Currently widely available as a research compound and through compounding pharmacies.
The above summarizes published research literature. This is not medical advice, a protocol, or a recommendation for use. This compound is supplied for laboratory research only.
Sermorelin is a 29-residue peptide with molecular formula C149H246N44O42S and molecular weight of approximately 3,357.9 Da.
The full structural data and release specifications are in the Compound Profile section above. Every lot ships with an independently verified Certificate of Analysis.
Each lot is independently verified by a 3rd-party analytical laboratory (STERIS Labs, Alcami Analytical, or equivalent) before release. Release specification is HPLC purity ≥ 99.5% (typical > 99.8%), mass spectrometry identity match within ±0.5 Da, water content < 5.0% Karl Fischer, and endotoxin < 0.25 EU/mL by LAL (USP <85>).
Look up the full COA for your lot at coa-lookup.html.
All compounds ship at ambient temperature in discreet, tamper-evident packaging. Lyophilized peptide powder is stable at room temperature for typical transit windows, which is why research-grade vendors ship this way. Tracked; signature not required.
Store unopened lyophilized product at 2–8°C protected from light. Once reconstituted, most peptides are stable at 2–8°C for approximately 28 days (compound-dependent).
Sermorelin was FDA-approved as Geref (Serono) for diagnostic use in GH-deficient children, though the brand was discontinued. Currently widely available as a research compound and through compounding pharmacies.
All PeptideBros compounds are sold strictly as chemical reference materials for in-vitro laboratory research. They are not for human consumption.
HPLC-verified. Mass-spec confirmed. Ambient-stable transit. The paperwork other vendors hope you never ask for.