⚠ FOR LABORATORY RESEARCH USE ONLY · NOT FOR HUMAN CONSUMPTION · QUALIFIED RESEARCHERS 21+
// PB-0023 Peptide Hormone / Reproductive

Kisspeptin-10

GnRH pulse regulator.

Kisspeptin-10 is the C-terminal decapeptide of the KISS1 gene product — the master regulator of GnRH secretion at the apex of the hypothalamic-pituitary-gonadal axis. Its discovery revolutionized reproductive endocrinology in the 2000s. Supplied as research-grade material with 3rd-party HPLC verification and full Certificate of Analysis per lot.

01

Compound profile.

// CHEMICAL & STRUCTURAL SPEC — KISSPEPTIN-10
MOLECULAR FORMULA
C63H83N17O14
Peptide · hormone / reproductive class.
MOLECULAR WEIGHT
1,302.4 Da
Monoisotopic / reported mass.
CHAIN LENGTH
10 aa
Primary structure residues.
ORIGIN
KISS1 gene product
Source or discovery context.
STUDIED PATHWAYS
KISS1R (GPR54)
Reported in published literature.
REPORTED HALF-LIFE
~5 min
Rapid clearance.
HPLC PURITY
99.8%
Minimum release spec · typical >99.9%.
APPEARANCE
White lyo.
White to off-white lyophilized form.
// PRIMARY STRUCTURE
Tyr–Asn–Trp–Asn–Ser–Phe–Gly–Leu–Arg–Phe-NH₂

// The C-terminal 10 residues (metastin 45-54) of the 145-residue KISS1 gene product. This decapeptide retains full biological activity at the KISS1R receptor. The C-terminal Phe-amide is essential for receptor binding.
02

What the literature reports.

Kisspeptin-10 is the C-terminal decapeptide of the KISS1 gene product — the master regulator of GnRH secretion at the apex of the hypothalamic-pituitary-gonadal axis. Its discovery revolutionized reproductive endocrinology in the 2000s.

Reported mechanism

Binds KISS1R (GPR54) on hypothalamic GnRH neurons, triggering GnRH release and thereby driving downstream LH/FSH secretion. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism. Published literature describes kisspeptin as a potential trigger of puberty and regulator of reproductive cyclicity.

Research context

Extensively studied in reproductive endocrinology. Has been tested in clinical trials for hypothalamic amenorrhea, ovulation induction, and GnRH deficiency. Not yet an FDA-approved therapeutic.

The above summarizes published research literature. This is not medical advice, a protocol, or a recommendation for use. This compound is supplied for laboratory research only.

03

Storage & release.

SHIP TEMP
Ambient
Lyophilized; stable at room temp in transit.
UNOPENED
Refrigerate
Lyophilized, protected from light.
RECONSTITUTED
~28 days
At 2–8°C; never freeze solutions.
RELEASE DOC
COA · per lot
3rd-party analytical · attached at ship.
lab@peptidebros:~$ cat release.kisspeptin.KISS-26-Q2-0036.log
// lot release record
compound Kisspeptin-10 (C63H83N17O14)
lot.id KISS-26-Q2-0036
class peptide
mw.theoretical 1,302.4 Da
mw.observed 1,302.4 Da  [PASS]
purity.hplc 99.91%  [> 99.5% spec]
endotoxin < 0.125 EU/mL  [PASS]
sterility no growth  [PASS]
release.status RELEASED
04

Common questions.

What's the molecular profile?+

Kisspeptin-10 is a 10-residue peptide with molecular formula C63H83N17O14 and molecular weight of approximately 1,302.4 Da.

The full structural data and release specifications are in the Compound Profile section above. Every lot ships with an independently verified Certificate of Analysis.

How is purity verified?+

Each lot is independently verified by a 3rd-party analytical laboratory (STERIS Labs, Alcami Analytical, or equivalent) before release. Release specification is HPLC purity ≥ 99.5% (typical > 99.8%), mass spectrometry identity match within ±0.5 Da, water content < 5.0% Karl Fischer, and endotoxin < 0.25 EU/mL by LAL (USP <85>).

Look up the full COA for your lot at coa-lookup.html.

How is the compound shipped and stored?+

All compounds ship at ambient temperature in discreet, tamper-evident packaging. Lyophilized peptide powder is stable at room temperature for typical transit windows, which is why research-grade vendors ship this way. Tracked; signature not required.

Store unopened lyophilized product at 2–8°C protected from light. Once reconstituted, most peptides are stable at 2–8°C for approximately 28 days (compound-dependent).

Is this compound FDA-approved?+

Extensively studied in reproductive endocrinology. Has been tested in clinical trials for hypothalamic amenorrhea, ovulation induction, and GnRH deficiency. Not yet an FDA-approved therapeutic.

All PeptideBros compounds are sold strictly as chemical reference materials for in-vitro laboratory research. They are not for human consumption.

Every lot,
on paper.

HPLC-verified. Mass-spec confirmed. Ambient-stable transit. The paperwork other vendors hope you never ask for.