⚠ FOR LABORATORY RESEARCH USE ONLY · NOT FOR HUMAN CONSUMPTION · QUALIFIED RESEARCHERS 21+
// PB-0034 Peptide Immune / Longevity

Thymosin α-1

Thymic peptide · FDA approved (ex-US).

Thymosin α-1 is a 28-residue acetylated peptide originally isolated from thymic fraction 5 in the 1970s by Goldstein's group. It is one of the most clinically developed thymic peptides, approved (as Zadaxin) in multiple countries for immune modulation. Supplied as research-grade material with 3rd-party HPLC verification and full Certificate of Analysis per lot.

01

Compound profile.

// CHEMICAL & STRUCTURAL SPEC — THYMOSIN Α-1
MOLECULAR FORMULA
C129H215N33O55
Peptide · immune / longevity class.
MOLECULAR WEIGHT
3,108.3 Da
Monoisotopic / reported mass.
CHAIN LENGTH
28 aa
Primary structure residues.
ORIGIN
Synthetic · identical to thymic
Source or discovery context.
STUDIED PATHWAYS
TLR signaling · T-cell function
Reported in published literature.
REPORTED HALF-LIFE
~2 hr
Short–moderate t½.
HPLC PURITY
99.8%
Minimum release spec · typical >99.9%.
APPEARANCE
White lyo.
White to off-white lyophilized form.
// PRIMARY STRUCTURE
Ac-Ser–Asp–Ala–Ala–Val–Asp–Thr–Ser–Ser–Glu–Ile–Thr–Thr–Lys–Asp–Leu–Lys–Glu–Lys–Lys–Glu–Val–Val–Glu–Glu–Ala–Glu–Asn

// N-acetylated 28-residue peptide. Originally isolated from thymic fraction 5 by Allan Goldstein's laboratory, subsequently characterized and synthesized. Structurally identical to the endogenous thymic peptide.
02

What the literature reports.

Thymosin α-1 is a 28-residue acetylated peptide originally isolated from thymic fraction 5 in the 1970s by Goldstein's group. It is one of the most clinically developed thymic peptides, approved (as Zadaxin) in multiple countries for immune modulation.

Reported mechanism

Published literature describes Thymosin α-1 as a TLR9 (Toll-like receptor 9) ligand on dendritic cells, driving Th1-polarized immune responses. Reported effects include enhancement of T-cell differentiation, maintenance of peripheral T-cell repertoire diversity, and modulation of cytokine production profiles.

Regulatory status

Approved as Zadaxin (SciClone Pharmaceuticals) in over 30 countries for chronic hepatitis B, immune reconstitution in cancer, and as a vaccine adjuvant. Not FDA-approved in the United States.

The above summarizes published research literature. This is not medical advice, a protocol, or a recommendation for use. This compound is supplied for laboratory research only.

03

Storage & release.

SHIP TEMP
Ambient
Lyophilized; stable at room temp in transit.
UNOPENED
Refrigerate
Lyophilized, protected from light.
RECONSTITUTED
~28 days
At 2–8°C; never freeze solutions.
RELEASE DOC
COA · per lot
3rd-party analytical · attached at ship.
lab@peptidebros:~$ cat release.thymosin-alpha-1.TMA-26-Q2-0077.log
// lot release record
compound Thymosin α-1 (C129H215N33O55)
lot.id TMA-26-Q2-0077
class peptide
mw.theoretical 3,108.3 Da
mw.observed 3,108.3 Da  [PASS]
purity.hplc 99.91%  [> 99.5% spec]
endotoxin < 0.125 EU/mL  [PASS]
sterility no growth  [PASS]
release.status RELEASED
04

Common questions.

What's the molecular profile?+

Thymosin α-1 is a 28-residue peptide with molecular formula C129H215N33O55 and molecular weight of approximately 3,108.3 Da.

The full structural data and release specifications are in the Compound Profile section above. Every lot ships with an independently verified Certificate of Analysis.

How is purity verified?+

Each lot is independently verified by a 3rd-party analytical laboratory (STERIS Labs, Alcami Analytical, or equivalent) before release. Release specification is HPLC purity ≥ 99.5% (typical > 99.8%), mass spectrometry identity match within ±0.5 Da, water content < 5.0% Karl Fischer, and endotoxin < 0.25 EU/mL by LAL (USP <85>).

Look up the full COA for your lot at coa-lookup.html.

How is the compound shipped and stored?+

All compounds ship at ambient temperature in discreet, tamper-evident packaging. Lyophilized peptide powder is stable at room temperature for typical transit windows, which is why research-grade vendors ship this way. Tracked; signature not required.

Store unopened lyophilized product at 2–8°C protected from light. Once reconstituted, most peptides are stable at 2–8°C for approximately 28 days (compound-dependent).

Is this compound FDA-approved?+

Approved as Zadaxin (SciClone Pharmaceuticals) in over 30 countries for chronic hepatitis B, immune reconstitution in cancer, and as a vaccine adjuvant. Not FDA-approved in the United States.

All PeptideBros compounds are sold strictly as chemical reference materials for in-vitro laboratory research. They are not for human consumption.

Every lot,
on paper.

HPLC-verified. Mass-spec confirmed. Ambient-stable transit. The paperwork other vendors hope you never ask for.