⚠ FOR LABORATORY RESEARCH USE ONLY · NOT FOR HUMAN CONSUMPTION · QUALIFIED RESEARCHERS 21+
// PB-0031 Peptide Cognitive

Semax

ACTH(4-10) heptapeptide.

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone fragment 4-7 (ACTH 4-7), developed at the Institute of Molecular Genetics. Like Selank, it is officially registered as a medicinal product in Russia. Supplied as research-grade material with 3rd-party HPLC verification and full Certificate of Analysis per lot.

01

Compound profile.

// CHEMICAL & STRUCTURAL SPEC — SEMAX
MOLECULAR FORMULA
C37H51N9O10S
Peptide · cognitive class.
MOLECULAR WEIGHT
813.9 Da
Monoisotopic / reported mass.
CHAIN LENGTH
7 aa
Primary structure residues.
ORIGIN
Russian Academy of Sciences
Source or discovery context.
STUDIED PATHWAYS
BDNF · NGF · monoamine
Reported in published literature.
REPORTED HALF-LIFE
Short
Very short parenteral.
HPLC PURITY
99.8%
Minimum release spec · typical >99.9%.
APPEARANCE
White lyo.
White to off-white lyophilized form.
// PRIMARY STRUCTURE
Met–Glu–His–Phe–Pro–Gly–Pro

// Methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline. A synthetic analog of the ACTH fragment 4-7 with a C-terminal Pro-Gly-Pro tripeptide extension for metabolic stability. The fragment retains neurotropic activity of ACTH without corticotropic activity.
02

What the literature reports.

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone fragment 4-7 (ACTH 4-7), developed at the Institute of Molecular Genetics. Like Selank, it is officially registered as a medicinal product in Russia.

Reported mechanism

Published work describes Semax as upregulating BDNF and NGF expression in the CNS, modulating hippocampal and prefrontal monoamine neurotransmission, and providing neuroprotection in ischemic and stress models. The C-terminal extension blocks rapid enzymatic degradation characteristic of ACTH fragments.

Regulatory status

Registered in Russia for cerebrovascular disease, cognitive function, and ischemic stroke. Not FDA-approved. Widely available as a research compound and nootropic.

The above summarizes published research literature. This is not medical advice, a protocol, or a recommendation for use. This compound is supplied for laboratory research only.

03

Storage & release.

SHIP TEMP
Ambient
Lyophilized; stable at room temp in transit.
UNOPENED
Refrigerate
Lyophilized, protected from light.
RECONSTITUTED
~28 days
At 2–8°C; never freeze solutions.
RELEASE DOC
COA · per lot
3rd-party analytical · attached at ship.
lab@peptidebros:~$ cat release.semax.SMX-26-Q2-0031.log
// lot release record
compound Semax (C37H51N9O10S)
lot.id SMX-26-Q2-0031
class peptide
mw.theoretical 813.9 Da
mw.observed 813.9 Da  [PASS]
purity.hplc 99.91%  [> 99.5% spec]
endotoxin < 0.125 EU/mL  [PASS]
sterility no growth  [PASS]
release.status RELEASED
04

Common questions.

What's the molecular profile?+

Semax is a 7-residue peptide with molecular formula C37H51N9O10S and molecular weight of approximately 813.9 Da.

The full structural data and release specifications are in the Compound Profile section above. Every lot ships with an independently verified Certificate of Analysis.

How is purity verified?+

Each lot is independently verified by a 3rd-party analytical laboratory (STERIS Labs, Alcami Analytical, or equivalent) before release. Release specification is HPLC purity ≥ 99.5% (typical > 99.8%), mass spectrometry identity match within ±0.5 Da, water content < 5.0% Karl Fischer, and endotoxin < 0.25 EU/mL by LAL (USP <85>).

Look up the full COA for your lot at coa-lookup.html.

How is the compound shipped and stored?+

All compounds ship at ambient temperature in discreet, tamper-evident packaging. Lyophilized peptide powder is stable at room temperature for typical transit windows, which is why research-grade vendors ship this way. Tracked; signature not required.

Store unopened lyophilized product at 2–8°C protected from light. Once reconstituted, most peptides are stable at 2–8°C for approximately 28 days (compound-dependent).

Is this compound FDA-approved?+

Registered in Russia for cerebrovascular disease, cognitive function, and ischemic stroke. Not FDA-approved. Widely available as a research compound and nootropic.

All PeptideBros compounds are sold strictly as chemical reference materials for in-vitro laboratory research. They are not for human consumption.

Every lot,
on paper.

HPLC-verified. Mass-spec confirmed. Ambient-stable transit. The paperwork other vendors hope you never ask for.