Cyclic α-MSH analog.
Melanotan II is a cyclic heptapeptide α-MSH analog developed at the University of Arizona in the 1980s. The cyclic structure confers high potency at melanocortin receptors. It is the direct precursor to bremelanotide (PT-141). Supplied as research-grade material with 3rd-party HPLC verification and full Certificate of Analysis per lot.
Melanotan II is a cyclic heptapeptide α-MSH analog developed at the University of Arizona in the 1980s. The cyclic structure confers high potency at melanocortin receptors. It is the direct precursor to bremelanotide (PT-141).
Potent non-selective agonist of MC1R, MC3R, MC4R, and MC5R. The MC1R activity drives pigmentation effects; MC4R activity is implicated in the reported effects on sexual function and appetite suppression. Non-selectivity is a notable distinguishing feature from the later-developed PT-141 (which is modestly MC4R-selective).
Never approved for any indication. Widely available as a research compound. Notable for a range of reported off-target effects due to non-selective melanocortin receptor agonism; documented reports of adverse skin pigmentation changes and atypical melanocytic lesions in research and self-administration contexts.
The above summarizes published research literature. This is not medical advice, a protocol, or a recommendation for use. This compound is supplied for laboratory research only.
Melanotan II is a 7-residue peptide with molecular formula C50H69N15O9 and molecular weight of approximately 1,024.2 Da.
The full structural data and release specifications are in the Compound Profile section above. Every lot ships with an independently verified Certificate of Analysis.
Each lot is independently verified by a 3rd-party analytical laboratory (STERIS Labs, Alcami Analytical, or equivalent) before release. Release specification is HPLC purity ≥ 99.5% (typical > 99.8%), mass spectrometry identity match within ±0.5 Da, water content < 5.0% Karl Fischer, and endotoxin < 0.25 EU/mL by LAL (USP <85>).
Look up the full COA for your lot at coa-lookup.html.
All compounds ship at ambient temperature in discreet, tamper-evident packaging. Lyophilized peptide powder is stable at room temperature for typical transit windows, which is why research-grade vendors ship this way. Tracked; signature not required.
Store unopened lyophilized product at 2–8°C protected from light. Once reconstituted, most peptides are stable at 2–8°C for approximately 28 days (compound-dependent).
Never approved for any indication. Widely available as a research compound. Notable for a range of reported off-target effects due to non-selective melanocortin receptor agonism; documented reports of adverse skin pigmentation changes and atypical melanocytic lesions in research and self-administration contexts.
All PeptideBros compounds are sold strictly as chemical reference materials for in-vitro laboratory research. They are not for human consumption.
HPLC-verified. Mass-spec confirmed. Ambient-stable transit. The paperwork other vendors hope you never ask for.